Selection of protein therapeutic candidates using Biacore T100 A critical role for high-resolution kinetics in assessment of engineered human Fabs

Protein therapeutics, such as antibodies and antibody fragments, are becoming increasingly important. While these proteins offer unparalleled benefits in terms of targeting and specificity, issues such as the risk of immunogenic reactions in patients and the potentially high cost of the end product goods also present potential problems for pharmaceutical companies. To minimize these and other challenges, efficient selection and optimization of protein therapeutics is essential throughout the development process. Real-time protein interaction analysis is an invaluable characterization technique that contributes to all phases of protein therapeutic discovery programs, from basic research to selection and optimization of therapeutic candidates, to immunogenicity studies in preclinical and clinical trials. Application Note 81 Biacore systems GE Healthcare